the NOT WORTH ITS OWN THREAD thread could be revived

Music posts are a bannable offense.
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Sun Nov 25, 2018 8:31 am

deverning

and then deleting my argument as a form of self-care i guess whatever

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cxwx wrote:
Sat Nov 24, 2018 10:19 pm
Glub wrote:
Sat Nov 24, 2018 9:10 pm
MeatGrease wrote:
Sat Nov 24, 2018 8:59 pm
cxwx wrote:
Mon Nov 19, 2018 2:31 pm

I like the video where he makes fun of the old lady who worked at Walmart for 18 years and still isn’t a manager. Then he acts like he’s really pwned her because she said Walmart makes billions a day with “they only make 495 million dollars a year” while he sits there in his fucking pac man shirt or whatever. A completely unlikeable pile of shit.
:lol: :lol: no surprise at all you strongly identify with this shit. After all, they're fat old retards who wasted their lives so basically the spitting image of you.

:lol:
Lord knows, he'll never be held in the same high-esteem as a trail-fixin; secret gay.
Maybe one day he can be a balloon head with a stupid fucking YouTube channel. It works for dragon lord Frodo and jofa. Come on menschgrease. Get that google check.
What are the chances that a recently adolescent nerd who harbors cartoonish fantasies of being a noble warrior-priest Germanic Chieftain doesn't have a constantly updated YouTube channel?
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I can trace my ancestry all the way back to historic germanic tribal chieftains in fact.

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Tue Nov 27, 2018 4:43 pm

a piece of Dead's skull for sale
http://serialkillersink.net/skistore/%C ... gment.html :shock:

probably would've been smarter to sell this AFTER the movie comes out?
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Tue Nov 27, 2018 9:48 pm

some chinese scientist modified the genome of a couple of embryos and the resulting twin baby girls were just born. he did this in defiance of basically every current ethical guideline and the worst part is that the change he made - removing a protein that makes you immune to HIV - is probably doing more harm than good since it increases susceptibility to west nile and influenza. now the guy is at some worldwide conference on tweaking the human genome and he's just getting ROASTED by the community. apparently he's a physicist by training and doesn't seem to have a clue what he's even done or why.

long story short humanity just took another step towards brave new world stuff and it's all thanks to a dummy.
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Wed Nov 28, 2018 11:24 am

isn't uh, that basically the business model of all new tech companies (in the united states)? i mean apart from ones that exist only to burn VC

technological innovation -> profit model predicated on super dubious ethics -> performative ethical reflection -> double down on the bad thing when it's clear the regulatory state is 100% hands-off

the people that care about the ethics will care about the ethics; the people that care about money will care about money. there's no reconciling the two in any way except under pain of sovereign violence—which i am now unabashedly supporting. make CRISPR baby tinkering a class AAA super combo felony again!

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Wed Nov 28, 2018 2:26 pm

Why would he fuck with the genome to make someone at greater risk of disease ? Isn’t the benefit of altering genes was to make people super soldiers, and failing that, make them less susceptible to the illnesses and hardships passed along genetically ?

A thousand apologies if I’m totally misunderstanding this, as my expertise lies in the somewhat removed field of getting hit in the face
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Wed Nov 28, 2018 5:14 pm

riley you're spot on. in this case they enrolled would-be-parent couples where the dad is HIV+, and I think this was just to have a sympathetic person who would find it SUPER IMPORTANT to have an HIV-immune kid. the consent procedure was a total sham and they didn't inform the parents of any of the potential risks/downsides LOL

andrew yeah I guess this is not that much of a break from uber in your framing system, but it's pretty novel to be making genetic changes using an imperfect molecular scalpel on an embryo... just to decrease the risk of getting a thing that is pretty readily avoided in places where genetic engineering is going on? this guy didn't do it for $$$ fwiw. I've heard of a few start-ups that were keen to make GATTACA babies but I feel like they bailed once they realized it would be a shit-show IRL. those efforts now take place via preimplantation genetic diagnosis, where they can get a bunch of embryos ready for IVF, genome sequence them, and then let the parents pick eye/hair color, skin tone, etc. before one gets popped in the over.

[side note: I find it unbelievable that you can take a proto-babby made of just 8 cells, pluck one out to destroy in the process of genome sequencing, and somehow the other 7 cells are like "oh, we need another cell apparently" and they just make another one. how the fuck?]

but yeah on the consequences front: we'll see what happens to this dude. IIRC china once executed their former FDA(equivalent) director for approving fake drugs. so maybe this guy's dead?

there's been tons of handwringing over everyone saying "OF COURSE china did this", but like... yes, of course china did this. that's just a reasonable expectation based on facts.
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Wed Nov 28, 2018 5:17 pm

hahaha actual excerpt from an article about the mad scientist guy trying to do crash-course in bioethics. from the tale of the bioethicist & unwitting mentor to a madman:
He made his thumb and forefinger nearly touch and asked, “You mean to tell me that something this small is as important as someone’s child?”
ahhh, the enviable luxury of never having to deal with a pro-life christian ever
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Wed Nov 28, 2018 8:31 pm

Necrometer wrote:
Wed Nov 28, 2018 5:14 pm
there's been tons of handwringing over everyone saying "OF COURSE china did this", but like... yes, of course china did this. that's just a reasonable expectation based on facts.
Is there a "human rights v chinese medical science" thing going on, like the terrorim/islam perma-debate? Maybe I'm misreading what you posted I DONT KNOW
canon.docre wrote:I will not be seduced by the cheap showiness of nature.

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Thu Nov 29, 2018 7:30 am

Eight Bit Alien wrote:
Wed Nov 28, 2018 8:31 pm
Necrometer wrote:
Wed Nov 28, 2018 5:14 pm
there's been tons of handwringing over everyone saying "OF COURSE china did this", but like... yes, of course china did this. that's just a reasonable expectation based on facts.
Is there a "human rights v chinese medical science" thing going on, like the terrorim/islam perma-debate? Maybe I'm misreading what you posted I DONT KNOW
If not now, there will be soon. We haven't really had a legit Asian target in quite some time if you don't count Trump's soft economic racism towards them.
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Thu Nov 29, 2018 7:46 am

Necrometer wrote:
Wed Nov 28, 2018 5:14 pm
andrew yeah I guess this is not that much of a break from uber in your framing system, but it's pretty novel to be making genetic changes using an imperfect molecular scalpel on an embryo... just to decrease the risk of getting a thing that is pretty readily avoided in places where genetic engineering is going on? this guy didn't do it for $$$ fwiw. I've heard of a few start-ups that were keen to make GATTACA babies but I feel like they bailed once they realized it would be a shit-show IRL. those efforts now take place via preimplantation genetic diagnosis, where they can get a bunch of embryos ready for IVF, genome sequence them, and then let the parents pick eye/hair color, skin tone, etc. before one gets popped in the over.
more like popped in the ulver. less like that, actually

the genetic prescreens for IVF still have substantial false negative rates (friends of ours just had one where the result was the kind of doubleplus ungood chromosomal issue where it's destroy or wait for inevitable self-destruction, fucking heartbreaking man) which can break in one of two ways re: the future market of this shit. the first is yeah, avoid the blowback of being a boutique baby company when model 337 comes out with webbed lungs and a prehensile clit. the second is professionals, already delaying and freezing eggs to accrue enough capital to afford being a parent that is also an entrenched c-suite monster, who demand that their precious idiot son-to-be rohan have heterochromia and a fatal peanut allergy to build character

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Thu Nov 29, 2018 3:44 pm

:lol:
Eight Bit Alien wrote:
Wed Nov 28, 2018 8:31 pm
Necrometer wrote:
Wed Nov 28, 2018 5:14 pm
there's been tons of handwringing over everyone saying "OF COURSE china did this", but like... yes, of course china did this. that's just a reasonable expectation based on facts.
Is there a "human rights v chinese medical science" thing going on, like the terrorim/islam perma-debate? Maybe I'm misreading what you posted I DONT KNOW
you are reading me right

I don't know that many medical horror details beyond vague steterotypes, but their science ethics are all sorts of fucked. most of it centers around the pressure to publish lots of papers in good journals. usually the papers get sent around to experts in the field, who say if the work is garbage or not, and you need a good review to get into a good journal. importantly, you can suggest your own reviewers. so in china when some shady scientist is suggesting reviewers they'll be like "please have bill nye read this - his email is [email protected]" and often the editor will just send the review to that address when it's REALLY being sent to the reviewer's buddy or, more hilariously, someone at a company whose sole purpose is to write fake reviews!

sorry... that's not very juicy. embryos just aren't worth much there as evidenced by that borat-esque anecdote above, along with the apparently painless acceptance of the one-child policy, which exacerbated pressures to make sure a son resulted, in turn inspiring zillions of lady-babies being aborted because of their sex. for the last ~20 years there are about 7 boys born for every 6 girls. not that insane, but still...

there's not a lot of medical science atrocity going on before this recent gaffe, but I think the "compulsory doping for the olympics" backdrop gave people the impression that they're going to be ethically lax but also driven to do something first.

sorry this post sucks. maybe I am forgetting something!
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Fri Nov 30, 2018 11:10 pm

FUCK OFF AFTERSHOCKS

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Sat Dec 01, 2018 12:58 pm

holy shit... 7? i hope your shit is not wrecked :lhug:
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Sat Dec 01, 2018 4:09 pm

I lucked out. no damage just a big mess to clean up.

https://weather.com/news/news/2018-11-3 ... ke-impacts

TREMBLOR.

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Sun Dec 02, 2018 7:54 am

aggressively researching indoor mini golf courses in an attempt to capitalize on an anchor store closing in our nearby mall

a two level putt-putt course is a natural draw, right?!?!?

floor one would be kid-friendly, floor two is like aggressively landscaped and designed to fuck with pro putters, probably enough room for four 18-hole courses

exit through the gift shop motherfuckers

jungle theme!?!?!?

i'm in the weeds of a real estate development analysis for a restaurant and i don't want to keep going so here's where i'm at now

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Sun Dec 02, 2018 8:58 am

https://www.news.com.au/technology/scie ... fede7b4ab3

Face transplant patient reveals his remarkable recovery.

A man who had gruelling face transplant surgery has revealed his “breathtaking” transformation. WARNING: Graphic images

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Sun Dec 02, 2018 10:51 am

First snow of the year, 20 foot tree branch breaks off in my backyard.
History is a nightmare from which I am trying to awake.

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Sun Dec 02, 2018 5:42 pm

fvbtvs - i wasn't paying attention and thought the "before" footage was post-surgery and :shock: !!! anyway good for that guy

andrew: SF has an artisanal indoor putt-putt place (12 holes) that is pretty cool. i think it's a near-ideal solution to making both kids & adults happy. just hire dozens of liberal arts imagineers and crank the whimsy to 11.


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Mon Dec 03, 2018 5:42 am

flag on the play: i’m in the Midwest. whatever i’d do would have to appeal to both a huge college contingent and the mewling hogs that live in the country. so like, less twee, more rainforest cafe

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Mon Dec 03, 2018 12:52 pm

is the escape room market saturated there yet? barcades out in force?
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Mon Dec 03, 2018 4:23 pm

my old landlord owns the only escape room in town, it does... okay? i don't think any place qualifies as a barcade: the campus bars won't waste the space that can be filled with froshies barfing out soco and lime like the world's least popular lawn decoration, and the "adult" bars are too busy trying to get that food money. honestly a dave & buster's would absolutely dominate out here with the spergy stem kids and the emotionally stunted pickup drivers

honestly i'll just wait until governor ham salad opens up marijuana for recreational purposes and either a.) get into that business or b.) get so high i don't give a shit about a side hustle anymore

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Mon Dec 03, 2018 5:42 pm

am i the only person in the world that loves internet censorship?

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