oh yeaaaaaaaaaahpre-diabetes seems to cause weight gain
it does, doesn't it!?
oh yeaaaaaaaaaahpre-diabetes seems to cause weight gain
...And run up livestock chutes into the waiting ovens.Cryptoplasty wrote:I feel that screen captures like this should not have the persons name covered up. These people need to be exposed.
I don't think that is so crazy. a link would be appreciated - I didn't find that on PubMed and my top google hit delivered only LOLs:Geeheeb wrote:FUck I saw a study that seemed to indicate that insulin resistance might come before weight gain, Ross. Will try to post. It was because of CONTENT of diet (carbs, processed food), not overload of calories.
PLoS One. 2010 Aug 16;5(8):e12191. doi: 10.1371/journal.pone.0012191.
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.
Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK.
Source
Department of Cell & Molecular Physiology, University of North Carolina at Chapel Hill, North Carolina, United States of America. shengli_ding@med.unc.edu
Abstract
BACKGROUND:
Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as the source of obesity-associated inflammation. Increasing evidence links intestinal bacteria to development of diet-induced obesity (DIO). This study tested the hypothesis that HF western diet and gut bacteria interact to promote intestinal inflammation, which contributes to the progression of obesity and insulin resistance.
METHODOLOGY/PRINCIPAL FINDINGS:
Conventionally raised specific-pathogen free (CONV) and germ-free (GF) mice were given HF or low fat (LF) diet for 2-16 weeks. Body weight and adiposity were measured. Intestinal inflammation was assessed by evaluation of TNF-alpha mRNA and activation of a NF-kappaB(EGFP) reporter gene. In CONV but not GF mice, HF diet induced increases in body weight and adiposity. HF diet induced ileal TNF-alpha mRNA in CONV but not GF mice and this increase preceded obesity and strongly and significantly correlated with diet induced weight gain, adiposity, plasma insulin and glucose. In CONV mice HF diet also resulted in activation of NF-kappaB(EGFP) in epithelial cells, immune cells and endothelial cells of small intestine. Further experiments demonstrated that fecal slurries from CONV mice fed HF diet are sufficient to activate NF-kappaB(EGFP) in GF NF-kappaB(EGFP) mice.
CONCLUSIONS/SIGNIFICANCE:
Bacteria and HF diet interact to promote proinflammatory changes in the small intestine, which precede weight gain and obesity and show strong and significant associations with progression of obesity and development of insulin resistance. To our knowledge, this is the first evidence that intestinal inflammation is an early consequence of HF diet which may contribute to obesity and associated insulin resistance. Interventions which limit intestinal inflammation induced by HF diet and bacteria may protect against obesity and insulin resistance.
but we all know old people are the pro-fat bloggers' best friend, since that's the age when a sea of subcutaneous lard will improve your chances of survivalGeeheeb wrote:That study deals with OLD people and their age-related changes in physiology, not spry young bloggers.
I think I remember what you're talking about... I can't remember what study it was.Geeheeb wrote:Fuck I saw a study that seemed to indicate that insulin resistance might come before weight gain, Ross. Will try to post. It was because of CONTENT of diet (carbs, processed food), not overload of calories.
ghost boner wrote:our cousins should fuck
ghost boner wrote:our cousins should fuck
Toilet Fleet wrote:dogs are shit tbqh
oh wow youre loyal, you know who else was loyal, fuckin goebbels
hahahahaCryptoplasty wrote:
The Bill wrote:Kids today with their artificially flavored kunt hands!
of course they willComments may be held for uploader approval.
ghost boner wrote:our cousins should fuck
Pisscubes wrote:Yeah. That's it. You don't feel happy being naked because of SOCIETY. That's it, exactly.
storm shadow wrote:This is what happens when people use the internet to get through adolescence, instead of drugs and heavy metal.