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Necrometer wrote:shit, I had assumed PCOS was caused by obesity, not the other way around

After contacting thousands of families in Finland, they came across 16 such pairs of identical adult twins, six male and 10 female. Once they got them into a lab and began testing, half of the obese twins quickly stood out.

“The first thing that popped out was when we looked at the amount of fat stored in their livers,” Dr. Naukkarinen said. “There was a significant difference.”

The 16 pairs were split evenly into two groups. In both, the average weight difference between the siblings was about 40 pounds. But in one group, the obese siblings had higher blood pressure, worse cholesterol levels and poorer measures of blood sugar and insulin production, as well as seven times the amount of fat in their livers. In the other group, the obese twins’ blood work and liver fat was similar to that of their lean twins.

Extensive tests of each person’s fat tissue revealed some other surprises. The healthy obese had 11 percent more adipocytes, or fat cells, in their subcutaneous fat tissue than their normal weight twins. But the unhealthy obese had 8 percent fewer fat cells than their leaner siblings, despite a higher body fat percentage.

The fat cells of the unhealthy obese were larger than those of any other group. They were swollen and riddled with inflammation.

Zap Rowsdower wrote:Is it that these fats got fat so fast (fatst?) that certain functions couldn't notice and haven't caught up?

Zap Rowsdower wrote:Is it that these fats got fat so fast (fatst?) that certain functions couldn't notice and haven't caught up?

Metabolically healthy obesity is found more frequently among younger adults, as a large study in the journal Diabetes Care demonstrated in August. There is growing evidence that it may be a transition state, and that if followed long enough, some, if not many, people in this category will eventually develop the expected metabolic disturbances.

That study followed several thousand Australians for up to a decade, about 12 percent of whom were initially deemed metabolically healthy obese. “We found that about a third of these people progressed down the road to being metabolically unhealthy,” said Sarah Appleton, a research fellow at the University of Adelaide. “Metabolically healthy obesity may essentially be a transient state.”

Zap Rowsdower wrote: