Big & Beautiful Thread of Sizeisms

[Necrometer]

^ that is some EXTREMELY contorted logic

pre-diabetes seems to cause weight gain

oh yeaaaaaaaaaah

it does, doesn't it!?

[Geeheeb]

FUck I saw a study that seemed to indicate that insulin resistance might come before weight gain, Ross. Will try to post. It was because of CONTENT of diet (carbs, processed food), not overload of calories.

[takeasneededforpain]

I feel that screen captures like this should not have the persons name covered up. These people need to be exposed.

...And run up livestock chutes into the waiting ovens.

[Necrometer]

FUck I saw a study that seemed to indicate that insulin resistance might come before weight gain, Ross. Will try to post. It was because of CONTENT of diet (carbs, processed food), not overload of calories.

I don't think that is so crazy. a link would be appreciated - I didn't find that on PubMed and my top google hit delivered only LOLs:


oh, is it this guy?

SPOILERSPOILER_SHOW

PLoS One. 2010 Aug 16;5(8):e12191. doi: 10.1371/journal.pone.0012191.
High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.
Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK.
Source

Department of Cell & Molecular Physiology, University of North Carolina at Chapel Hill, North Carolina, United States of America. shengli_ding@med.unc.edu
Abstract
BACKGROUND:

Obesity induced by high fat (HF) diet is associated with inflammation which contributes to development of insulin resistance. Most prior studies have focused on adipose tissue as the source of obesity-associated inflammation. Increasing evidence links intestinal bacteria to development of diet-induced obesity (DIO). This study tested the hypothesis that HF western diet and gut bacteria interact to promote intestinal inflammation, which contributes to the progression of obesity and insulin resistance.
METHODOLOGY/PRINCIPAL FINDINGS:

Conventionally raised specific-pathogen free (CONV) and germ-free (GF) mice were given HF or low fat (LF) diet for 2-16 weeks. Body weight and adiposity were measured. Intestinal inflammation was assessed by evaluation of TNF-alpha mRNA and activation of a NF-kappaB(EGFP) reporter gene. In CONV but not GF mice, HF diet induced increases in body weight and adiposity. HF diet induced ileal TNF-alpha mRNA in CONV but not GF mice and this increase preceded obesity and strongly and significantly correlated with diet induced weight gain, adiposity, plasma insulin and glucose. In CONV mice HF diet also resulted in activation of NF-kappaB(EGFP) in epithelial cells, immune cells and endothelial cells of small intestine. Further experiments demonstrated that fecal slurries from CONV mice fed HF diet are sufficient to activate NF-kappaB(EGFP) in GF NF-kappaB(EGFP) mice.
CONCLUSIONS/SIGNIFICANCE:

Bacteria and HF diet interact to promote proinflammatory changes in the small intestine, which precede weight gain and obesity and show strong and significant associations with progression of obesity and development of insulin resistance. To our knowledge, this is the first evidence that intestinal inflammation is an early consequence of HF diet which may contribute to obesity and associated insulin resistance. Interventions which limit intestinal inflammation induced by HF diet and bacteria may protect against obesity and insulin resistance.

[Geeheeb]

That study deals with OLD people and their age-related changes in physiology, not spry young bloggers.

[Geeheeb]

I will leave this here. Ross, this might give you some ideas on how YOU can get involved in the fight against (other people's) cellulite:

[Necrometer]

will watch that NSFW vid later

That study deals with OLD people and their age-related changes in physiology, not spry young bloggers.

but we all know old people are the pro-fat bloggers' best friend, since that's the age when a sea of subcutaneous lard will improve your chances of survival

[Geeheeb]

Extremely work safe.

[takeasneededforpain]

Fuck I saw a study that seemed to indicate that insulin resistance might come before weight gain, Ross. Will try to post. It was because of CONTENT of diet (carbs, processed food), not overload of calories.

I think I remember what you're talking about... I can't remember what study it was.

Human bodies, and their digestive/nutrient absorption processes are complex biochemical processes, and cannot be approximated by a bomb calorimeter. In other words, there is no such thing as calories in/calories out because the action of the endocrine system and the resident body's response to these hormones (most notably leptin and insulin) determines whether energy is used or stored.

And eating processed carbohydrate heavy garbage is a one-way trip to diabetes type-II town.
Also known as, where I was sitting three years ago... pre-diabetic, fat and miserable.

[Zap Rowsdower]

The day a fat tries instructing desirable women on subjective taste...

[Zap Rowsdower]

There you have it gents. A gunt and fupa are basically tits.

[Cryptoplasty]

[THE KILL]

hahahaha

[Raw Ting]

Fat female "comedians" are the worst species on the god damn planet

In 2 movies I watched in the last week there's been this fat australian blob farting around and trying go be funny, but ultimately making me suffer a fools fate

[riley-o]

Comments may be held for uploader approval.

of course they will

[Necrometer]

sadly (!?!?) she's perpetuating thin culture by pretending she doesn't find them absolutely irresistible

[Raw Ting]

no you don't understand, she had a buffalo chicken salad for lunch, with a diet coke. She earned those oreos.

[Raw Ting]

As Russ pointed out, its absurd for her to pretend to not enjoy Oreos. I have a female cousin who is obese, and she feigns disinterest in any junk food, yet cookies and other sweets have a habit of dissapearing when she's the only one in the room. I don't know who they think they're fooling...

[Zap Rowsdower]

[smellmyfinger]

Yeah. That's it. You don't feel happy being naked because of SOCIETY. That's it, exactly.

I blame mirrors.

[spacehamster]

I really need to barf, but I'm scared it's going to come out looking like her.

[Raw Ting]

Imagine the stench

[riley-o]

It's like Chuck Klosterman's head sitting on a bag of rotting cottage cheese that's inexplicably is wearing a bikini

[FVBTVS]

that is so much worse than the melted pussy on tuna can..

[Raw Ting]

wow, that's disturbingly accurate